This study investigates the role of strategic flexibility in enhancing administrative decision-making within international organizations operating in Gaza’s war-affected context, focusing on four key dimensions: resource, service, information, and human resource flexibility. The research employs a descriptive-analytical approach, targeting administrative and supervisory personnel across 87 registered international organizations in Gaza, with data collected through a comprehensive survey distributed to managers, department heads, and administrative assistants. Out of 174 questionnaires, 152 valid responses were analyzed, achieving an 85.4% response rate. The study’s scientific novelty lies in its empirical examination of how strategic flexibility functions under extreme uncertainty, offering a framework for humanitarian organizations to optimize decision-making in volatile environments. The author’s contribution includes identifying specific flexibility mechanisms that strengthen operational resilience, particularly through resource allocation, information adaptability, and workforce dynamics, while also revealing constraints imposed by donor policies on service flexibility. Practical significance stems from the findings that strategic flexibility significantly improves administrative decision-making, with resource, information, and human resource flexibility demonstrating strong positive impacts. Key conclusions highlight the importance of institutionalizing dynamic resource systems, adopting real-time data tools, cross-training staff, and advocating for donor policy reforms to enhance crisis responsiveness. The research underscores the critical role of strategic flexibility in humanitarian operations, providing actionable insights for organizations navigating complex emergencies. By demonstrating the measurable influence of flexibility dimensions on decision-making efficacy, the study advances both theoretical and practical understanding of adaptive management in conflict zones, with implications for policy and operational strategies in high-risk settings.